T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly

Potorac, I.; Petrossians, P.; Daly, A.F.; Alexopoulou, O.; Borot, S.; Sahnoun-Fathallah, M.; Castinetti, F.; Devuyst, F.; Jaffrain-Rea, M.; Briet, C.; Luca, F.; Lapoirie, M.; Zoicas, F.; Simoneau, I.; Diallo, A.M.; Muhammad, A.; Kelestimur, F.; Nazzari, E.; Garcia, C.R.; Webb, S.M.; Nunes, M.; Hana, V.; Pascal-Vigneron, V.; Ilovayskaya, I.; Nasybullina, F.; Achir, S.; Ferone, D.; Neggers Sebastian, J.C.; Delemer, B.; Petit, J.; Schoefl, C.; Raverot, G.; Goichot, B.; Rodien, P.; Corvilain, B.; Brue, T.; Schillo, F.; Tshibanda, L.; Maiter, D.; Bonneville, J.; Beckers, A.

Авторы: Potorac Iulia, Petrossians Patrick, Daly Adrian F., Alexopoulou Orsalia, Borot Sophie, Sahnoun-Fathallah Mona, Castinetti Frederic, Devuyst France, Jaffrain-Rea Marie-Lise, Briet Claire, Luca Florina, Lapoirie Marion, Zoicas Flavius, Simoneau Isabelle, Diallo Alpha M., Muhammad Ammar, Kelestimur Fahrettin, Nazzari Elena, Garcia Centeno Rogelio, Webb Susan M., Nunes Marie-Laure, Hana Vaclav, Pascal-Vigneron Veronique, Ilovayskaya Irena, Nasybullina Farida, Achir Samia, Ferone Diego, Neggers Sebastian J.C.M.M, Delemer Brigitte, Petit Jean-Michel, Schoefl Christof, Raverot Gerald, Goichot Bernard, Rodien Patrice, Corvilain Bernard, Brue Thierry, Schillo Franck, Tshibanda Luaba, Maiter Dominique, Bonneville Jean-Francois, Beckers Albert
Журнал: Endocrine-Related Cancer
Том: 23
Номер: 11
Год издания: 2016
Издательство: Society for Endocrinology
Местоположение издательства: United Kingdom
Первая страница: 871
Последняя страница: 881
DOI: 10.1530/ERC-16-0356
Аннотация: GH-secreting pituitary adenomas can be hypo-, iso- or hyper-intense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the relationship between T2-weighted signal intensity on diagnostic MRI and hormonal and tumoral responses to somatostatin analogs (SSA) as primary monotherapy. Acromegaly patients receiving primary SSA for at least 3 months were included in the study. Hormonal, clinical and general MRI assessments were performed and assessed centrally. We included 120 patients with acromegaly. At diagnosis, 84, 17 and 19 tumors were T2-hypo-, iso- and hyper-intense, respectively. SSA treatment duration, cumulative and mean monthly doses were similar in the three groups. Patients with T2-hypo-intense adenomas had median SSA-induced decreases in GH and IGF-1 of 88% and 59% respectively, which were significantly greater than the decreases observed in the T2-iso- and hyper-intense groups (P < 0.001). Tumor shrinkage on SSA was also significantly greater in the T2-hypo-intense group (38%) compared with the T2-iso- and hyper-intense groups (8% and 3%, respectively; P < 0.0001). The response to SSA correlated with the calculated T2 intensity: the lower the T2-weighted intensity, the greater the decrease in random GH (P < 0.0001, r = 0.22), IGF-1 (P < 0.0001, r = 0.14) and adenoma volume (P < 0.0001, r = 0.33). The T2-weighted signal intensity of GH-secreting adenomas at diagnosis correlates with hormone reduction and tumor shrinkage in response to primary SSA treatment in acromegaly. This study supports its use as a generally available predictive tool at diagnosis that could help to guide subsequent treatment choices in acromegaly.
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T2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegalyстатья