Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain traumaстатья
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Дата последнего поиска статьи во внешних источниках: 11 ноября 2019 г.
Аннотация:Objectives: To prove that our novel ethanolamine derivative (FDES) can normalize overall
movement and exploratory activity of rats with traumatic brain injury (TBI) owing to its
peculiar properties.
Materials and methods: TBI was modeled using controlled cortical impact injury (CCI)
model method. The resulting neurological deficit, efficacy of the novel agent and other
reference agents used were assayed in tests which evaluated overall movements and exploratory behavior of the rats. Finally, scopolamine in equimolar dose was used to estimate the
role of cholinergic system in the efficacy of our agent. The tests included: limb-placing, open
field, elevated plus maze, cylinder, and beam walking tests.
Results: Intraperitoneal administration of FDES at a dose of 10 mg/kg led to improvement of
fore- and hind-limb functions of rats with traumatic brain injury as was shown in “Limb placing”,
“Open field” “Cylinder” and “Beam walking” tests. The new agent had no effects on traumatized
rats behavior in the “Elevated Plus Maze” test. Simultaneous co-administration of scopolamine
with FDES reduced the beneficial effects of the latter in rats with trauma.
Conclusion: The neuroprotective effects of new agent were manifested in the reduction of
motor deficiencies, and exploratory activity in the CCI model rats. In comparison with
choline alfoscerate and citicoline, FDES showed more beneficial effects as were observed
in most of the tests, and did not negatively influence the traumatized rats psychologically.
Notably, it is possible that the neuroprotective influence of the new agent is mediated by its
actions on the cholinergic system.