Аннотация:This paper presents data on the composition of the low-enthalpy thermal waters from the unique Khoja-Obi-Garm field located at the central part of the southern slope of the Gissar Range, in the gorge of the Khoja-Obi-Garm River, at an altitude of 1740-1960 meters. In this place, the eponymous SPA-center was built. Groundwaters from springs and boreholes of Khoja-Obi-Garm SPA has temperatures from 57 to 93°C, high pH (up to 8) and low TDS (less than 0.5 g/l). The estimated subsurface temperatures for the same thermal waters vary from 140°C to 156°C and 193-197°C based on the silica and K/Na geothermometer temperatures consequently. These waters belong to Na–SO4–HCO3 type with high content of H2SiO3 (~140 mg/l), F (up to 18 mg/l) and Rn (up to 814 Bq/l). Thermodynamic speciation indicated that these groundwaters are supersaturated with clay minerals and low-temperature zeolites and undersaturated with carbonate and main alumosilicate minerals.