Modulation of critical brain dynamics using closed-loop neurofeedback stimulationстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 3 октября 2016 г.
Аннотация:Objective: EEG long-range temporal correlations (LRTCs) are a significant for both human cognition and braindisorders, but beyond suppression by sensory disruption, there are little means for influencing them noninvasively. We hypothesized that LRTCs could be controlled by engaging intrinsic neuroregulation throughclosed-loop neurofeedback stimulation.Methods: We used a closed-loop-stimulation paradigm where supra-threshold -waves trigger visual flashstimuli while the subject performs the standard eyes-closed resting-state task. As a “sham” control condition, we applied similar stimulus sequences without the neurofeedback.Results: Over three sessions, a significant difference in the LRTCs of -band oscillations (U = 89, p < 0.028,Wilcoxon rank sum test) and their scalp topography (T = -2.92, p < 0.010, T-test) emerged between theneurofeedback and sham conditions so that the LRTCs were stronger during neurofeedback than sham. Nochanges (F = 0.16, p > 0.69, ANOVA test) in the scalp topography of -band power were observed in eithercondition.Conclusions: This study provides proof-of-concept for that EEG LRTCs, and hence critical brain dynamics, canbe modulated with closed-loop stimulation in an automatic, involuntary fashion. We suggest that this modulationis mediated by an excitation-inhibition balance change achieved by the closed-loop neuroregulation.Significance: Automatic LRTC modulation opens novel avenues for both examining the functional roles of braincriticality in healthy subjects and for developing novel therapeutic approaches for brain disorders associated withabnormal LRTCs.