Early diagnosis of lung cancer based on proteome analysis of exhaled breath condensate

Fedorchenko, K.U.; Ryabokon, A.M.; Kononikhin, A.S.; Mitrofanov, S.I.; Barmin, V.V.; Pikin, O.V.; Anaev, E.H.; Gachok, I.V.; Popov, I.A.; Nikolaev, E.N.; Chuchalin, A.G.; Varfolomeev, S.D.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 октября 2016 г.

Авторы: Fedorchenko K.U., Ryabokon A.M., Kononikhin A.S., Mitrofanov S.I., Barmin V.V., Pikin O.V., Anaev E.H., Gachok I.V., Popov I.A., Nikolaev E.N., Chuchalin A.G., Varfolomeev S.D.
Журнал: Moscow University Chemistry Bulletin
Том: 71
Номер: 2
Год издания: 2016
Издательство: Allerton Press Inc.
Местоположение издательства: United States
Первая страница: 134
Последняя страница: 139
DOI: 10.3103/S0027131416020036
Аннотация: A comparative study of the exhaled-breath-condensate (EBC) proteome that was obtained for four donor groups was carried out using ion cyclotron resonance mass spectrometry with electrospray ionization. The groups included subjects with diagnosed lung cancer, chronic obstructive pulmonary disease, community-acquired pneumonia, and healthy nonsmoking control subjects. More than 300 proteins were identified, while 19 of them were found in the EBC samples of the donors who were diagnosed with lung cancer in the early stages and are potentially significant in the development of a diagnostic lung-cancer biomarker panel. It was shown that the EBC protein profiles of different donor groups can be distinguished. It may be possible to highlight a specific protein group that is typical for certain conditions/diseases of the respiratory system. Thus, the EBC analysis could be a promising non-invasive method for early diagnosis of lung cancer.
Добавил в систему: Митрофанов Сергей Игоревич

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