Местоположение издательства:[Washington, D.C.], United States
Первая страница:103
Аннотация:Functional and metabolic possibilities of different brain structures, under the effects of hyperthermia, hypoxia, and combinations of both, were studied by cytochemical and morphological methods in experiments performed on Wistar male white rats (weight 160 to 180 g) (age 5 to 6 months). Rats were subjected to simulated altitude of 8200 m, to hyperthermia at 40 C for 75 minutes, or to combined hyperthermia and hypoxia at 8200 m and 40 C for 75 minutes. After the experiment, rats were decapitated without use of anesthesia and RNA level and total and basic proteins in various neuron-glia systems were studied. Separate and combined effects of hyperthermia and hypoxia in the organism produced metabolic and morpholocigal changes in the brain structures studied. Reduction of RNA level and proteins in the neurons under combined effect of hyperthermia and hypoxia decreased their cytoplasm volume; overheating dehydrated the organism, reduced the volume of circulating blood, increased its viscosity, and reduced the hemoglobin level in the erythrocytes. The combined effect of hyperthermia and hypoxia, increasing at different rates, decreased the resistance of the animal to altitude considerably.
