Reaction of alpha,beta-unsaturated trifluoromethyl ketones with ethyl cyanoacetateстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:beta-Aryl-substituted alpha,beta-unsaturated trifluoromethyl ketones react with ethyl cyanoacetate to give the corresponding Michael addition products, ethyl 3-aryl-2-cyano-6,6,6-trifluoro-5-oxohexanoates, which are formed as mixtures of two diastereoisomers. The reaction time and product yield depend on electron-donating properties of the substituent in the initial ketone. The reaction is not accompanied by intramolecular cyclization of the Michael adducts.