Targeted intracellular delivery of photosensitizersстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:PSs are substances possessing a local action within target cells which is extended not more
than to tens of nanometers around sites of their subcellular localization due to the short
diusion distances of reactive oxygen species and free radicals produced upon illumination of
PSs. PSs used for PDT localize in various cytoplasmic membranous structures but are not
found in the most vulnerable intracellular sites for reactive oxygen species such as the cell
nucleus.
The data summarized here show that it is possible to design highly ecient molecular
constructs Ð PS carriers Ð with speci®c modules conferring cell-speci®c targeting,
internalization, intracellular vesicle escape, and targeting to the most vulnerable intracellular
compartments such as the nucleus. Nuclear targeting of these PS-carrying constructs resulted in
enhanced photodynamic activity, maximally about 2500-fold that of free PS. Future work
should optimise this approach, hopefully to the point at which tumor cells can be killed rapidly
and eciently, with a minimum of normal cell and tissue damage.