Increased motor cortex excitability during motor imagery in brain-computer interface trained subjects

Mokienko, O.A.; Chervyakov, A.V.; Kulikova, S.N.; Bobrov, P.D.; Chernikova, L.A.; Frolov, A.A.; Piradov, M.A.

Авторы: Mokienko Olesya A., Chervyakov Alexander V., Kulikova Sofia N., Bobrov Pavel D., Chernikova Liudmila A., Frolov Alexander A., Piradov Mikhail A.
Журнал: Frontiers in Computational Neuroscience
Том: 7
Год издания: 2013
Издательство: Frontiers Research Foundation
Местоположение издательства: Switzerland
DOI: 10.3389/fncom.2013.00168
Аннотация: Background: Motor imagery (MI) is the mental performance of movement without muscle activity. It is generally accepted that MI and motor performance have similar physiological mechanisms. Purpose: To investigate the activity and excitability of cortical motor areas during MI in subjects who were previously trained with an MI-based brain-computer interface (BCI). Subjects and Methods: Eleven healthy volunteers without neurological impairments (mean age, 36 years; range: 24–68 years) were either trained with an MI-based BCI (BCI-trained, n = 5) or received no BCI training (n = 6, controls). Subjects imagined grasping in a blocked paradigm task with alternating rest and task periods. For evaluating the activity and excitability of cortical motor areas we used functional MRI and navigated transcranial magnetic stimulation (nTMS). Results: fMRI revealed activation in Brodmann areas 3 and 6, the cerebellum, and the thalamus during MI in all subjects. The primary motor cortex was activated only in BCI-trained subjects. The associative zones of activation were larger in non-trained subjects. During MI, motor evoked potentials recorded from two of the three targeted muscles were significantly higher only in BCI-trained subjects. The motor threshold decreased (median = 17%) during MI, which was also observed only in BCI-trained subjects. Conclusion: Previous BCI training increased motor cortex excitability during MI. These data may help to improve BCI applications, including rehabilitation of patients with cerebral palsy.
Добавил в систему: Червяков Александр Владимирович

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