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Scorpion toxins interact with nicotinic acetylcholine receptorsстатья Тезисы
- Авторы: Kasheverov Igor E., Oparin Peter B., Zhmak Maxim N., Egorova Natalya S., Ivanov Igor A., Gigolaev Andrei M., Nekrasova Oksana V., Serebryakova Marina V., Kudryavtsev Denis S., Prokopev Nikita A., Hoang Anh N., Tsetlin Victor I., Vassilevski Alexander A., Utkin Yuri N.
- Журнал: FEBS Letters
- Год издания: 2019
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- DOI: 10.1002/1873-3468.13530
- Аннотация: Neurotoxins are among the main components of scorpion and snake venoms.Scorpion neurotoxins affect voltage-gated ion channels, while most snake neu-rotoxins target ligand-gated ion channels, mainly nicotinic acetylcholinereceptors (nAChRs). We report that scorpion venoms inhibita-bungarotoxinbinding to both muscle-type nAChR fromTorpedo californicaand neuronalhumana7 nAChR. Toxins inhibiting nAChRs were identified as OSK-1 (a-KTx family) fromOrthochirus scrobiculosusand HelaTx1 (j-KTx family)fromHeterometrus laoticus, both being blockers of voltage-gated potassiumchannels. With an IC50of 1.6lM, OSK1 inhibits acetylcholine-induced cur-rent through mouse muscle-type nAChR heterologously expressed inXenopusoocytes. Other well-characterized scorpion toxins from these families alsobind toTorpedonAChR with micromolar affinities. Our results indicate thatscorpion neurotoxins present target promiscuity.
- Добавил в систему: Кудрявцев Денис Сергеевич