Neuroprotective Effects of Methylene Blue In Vivo and In Vitroстатья
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Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
Аннотация:Focal unilateral traumatic brain injury in the sensorimotor cortical region disturbed the func-tions of contralateral limbs controlled by the damaged hemisphere. A single intravenous injec-tion of methylene blue (1 mg/kg) immediately before or 30 min after the injury significantly weakened functional disorders in the affected extremities. In vitro experiments showed that methylene blue effectively reduced death of cultured neurons provoked by paraquat or zinc ions producing the toxic effects on mitochondrias.