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Hafnium Oxide as a Nanoradiosensitizer under X-ray Irradiation of Aqueous Organic Systems: A Model Study Using the Spin-Trapping Technique and Monte Carlo Simulationsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.
- Авторы: Shiryaeva Ekaterina S., Baranova Irina A., Kiselev Grigorii O., Morozov Vladimir N., Belousov Alexandr V., Sherstiuk Anastasiia A., Kolyvanova Maria A., Krivoshapkin Pavel V., Feldman Vladimir I.
- Журнал: Journal of Physical Chemistry C
- Том: 123
- Номер: 45
- Год издания: 2019
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 27375
- Последняя страница: 27384
- DOI: 10.1021/acs.jpcc.9b08387
- Аннотация: Development of the physico-chemical basis for applications of nanoradiosensitizers for targeted treatment of tumours is one of the crucial issues of modern radiotherapy. Ceramic nanoparticles (NPs) composed of heavy metal oxides are considered as prospective sensitizers, particularly for X-ray treatment. The present study reports a novel approach to experimental simulation of the radiosensitizing effect of NPs in biomimetic systems based on quantification of radicals produced from organic component in concentrated aqueous organic solutions using spin trapping technique with EPR detection. This approach was first applied to X-ray irradiation (45 kVp) of aqueous methanol solutions systems containing different concentrations of hafnium oxide nanoparticles with an average diameter of ca. 84 nm (up to 1.8 wp). It was found that the amount of radicals produced from methanol at the same exposition time increased linearly with increasing content of HfO2 NPs. The effect can be reasonably explained by physical enhancement mechanism associated with efficient transfer of absorbed energy from the NPs to aqueous organic medium. The Monte-Carlo simulations were applied to calculate absorbed dose in the studied systems as a function of NP concentration. The experimental enhancement factor in formation of radicals (0.71 wp-1) was found to be slightly lower than the calculated coefficient of the absorbed dose enhancement (0.80 wp-1), which can be explained by partial self-absorption of generated secondary electrons inside rather bulky HfO2 nanoparticles. The proposed model approach may provide a rational ground for comparative studies of different nanoradiosensitizers and optimization of the NP size, photon energy and other factors.
- Добавил в систему: Ширяева Екатерина Сергеевна