Left-lateralized suppression of MEG auditory evoked transient response to click trains in children with ASD

Sysoeva, O.; Prokofyev, A.O.; Novikova, S.I.; Davletshina, M.A.; Galuta, I.A.; Stroganova, T.A.

Авторы: Sysoeva O., Prokofyev A.O., Novikova S.I., Davletshina M.A., Galuta I.A., Stroganova T.A.
Журнал: International Journal of Psychophysiology
Том: 108
Год издания: 2016
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 91
Аннотация: Introduction: Time-varying signals such as click trains have a dual representation in the auditory cortex (Lu et al., 2001). In addition to neurons with exactly stimulus-synchronized discharges as reflected by frequency following response, there are neural populations with discharges non-synchronized with each click but responsive to high-frequency stimulation. The latter type of neural activity provides the rate code of rapidly occurring sounds, which is especially important for speech processing, and might correlate with the amplitude of polyphasic auditory evoked response (AER) to the click train onset in human auditory cortex (Brugge et al., 2009). In this report, we focused on the AER triggered by the onset of 40-Hz click trains presented monaurally to the left and right ears in typically developing (TD) children and those with autism spectrum disorder (ASD). Methods: MEG was recorded in 30 ASD and 26 TD children aged 6-16 years while they were listening to monaurally presented 40-Hz clicks trains (train duration 0.5 s, inter-stimulus interval 2 s). Two MEG gradiometers (MEG0233 and MEG1343) with maximal AER amplitude at each hemisphere according to group statistics were chosen for the analysis. We evaluated both a magnitude of N1m response and inter-trial phase coherence (ITPC) within the N1m temporal window and frequency range (5-15 Hz). The sensitivity to speech and non-speech sounds was assessed via Sensory Profile Questionnaire (Dunn et al., 1999). Results: Grand average AER was characterized by prominent negative component (N1m) evident within 50-150 ms after the click train onset at the gradiometer channels located over the temporal lobes of both hemispheres. In terms of hemispheric asymmetry, monaural stimulation provoked larger and more reliable N1 response in the hemisphere contralateral to the stimulated ear for both TD and ASD groups. As compared to TD children, children with ASD demonstrated significantly reduced N1 magnitude at the left hemisphere and lower N1 ITPC at both hemispheres irrespective of the stimulated ear. In children with ASD the degree of left-hemispheric AER magnitude suppression was directly related to their unresponsiveness to speech sounds but not to their sensitivity to other auditory events. Conclusion. The study revealed that onset-related acoustic modulations of left-hemispheric brain activity is dampened in some children with ASD and this basic neural abnormality may importantly contribute to impaired processing of speech signals frequently observed in this neurodevelopmental disorder. The study has been supported by Russian Science Foundation grant #14-35-00060.
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Left-lateralized suppression of MEG auditory evoked transient response to click trains in children with ASDстатья