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mRNA expression of genes responsible for female hypogonadotrophic hypogonadismстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 июня 2017 г.
- Авторы: Loktionova A., Eneva N., Khusniyarova K., Nefedova L., Kim A.I., Dreval A., Ilovayskaya I.
- Журнал: Gynecological Endocrinology
- Том: 32
- Номер: 1
- Год издания: 2016
- Издательство: Parthenon Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 48
- Последняя страница: 48
- DOI: 10.3109/09513590.2016.1150635
- Аннотация: Patients: 9 women with hypogonadotropic hypogonadism (age from 18 to 28 yrs); duration of the disease from 2 to 15 years; 3 of them – amenorrhea I and 6 – amenorrhea II. Reasons of amenorrhea II were: stress, excessive exercises, rapid body weight loss, past use of oral contraceptives. The control group: 19 healthy women; age from 19 to 37 y.o.; with regular ovalutory menstrual cycle, some of them have children. mRNA expression of examined genes differed from normal patterns in each case of hypogonadotropic hypogonadism. Changes in GNRHR, GNRH1 and DUSP6 mRNA expression were found in most of cases. However variations of mRNA expression were multidirectional in each case and there was no similarity among expression profiles of patients according to amenorrhea type or anamnestic factors. According to our preliminary results, in women with hypogonadotropic hypogonadism the functional activity damage of ‘‘reproductive-responsible’’ genes could be found in each case. Probably mRNA expression measuring could be a perspective method for proving hypothalamo-pituitary level of reproductive disorders and may help to determine which genes should be tested for DNA impairment.
- Добавил в систему: Нефедова Лидия Николаевна