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The role of purinergic and adrenergic transmitters of the sympathetic system in the control of arterial blood pressure variabilityстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Tarasova O.S., Golubinskaya V.O., Kosiakov A.N., Borovik A.S., Timin E.N., Rodionov I.M.
- Журнал: Journal of the autonomic nervous system
- Том: 70
- Номер: 1-2
- Год издания: 1998
- Издательство: Elsevier/North Holland Biomedical Press.
- Местоположение издательства: Amsterdam, Netherlands
- Первая страница: 66
- Последняя страница: 70
- DOI: 10.1016/S0165-1838(98)00031-9
- Аннотация: Variability of mean arterial pressure (MAP) was examined in chronically instrumented, conscious, freely moving rats with pharmacologically altered efferent sympathetic influences on the cardiovascular system. MAP was recorded for 30 min beat-to-beat, using a computer under both control and experimental conditions: after administration of adrenoceptor antagonists (prazosin or phentolamine) or under P2X receptor inactivation produced either by desensitization with alpha,beta-methylene ATP or by PPADS blockade. Inhibition of adrenergic sympathetic effects on the cardiovascular system produced long-lasting and stable decrease in MAP. Prazosin did not modify MAP variability whereas phentolamine enhanced it. Under P2X receptor desensitization MAP decreased, the hypotensive effect being accompanied by a significant increase in MAP variability. A similar increase in MAP variability was observed after PPADS administration, while MAP level was not changed. Administration of PPADS in combination with phentolamine increased MAP variability more significantly than each of the drugs given separately. Changes in MAP variability under the various experimental conditions were not consistently correlated with changes in heart rate variability. We propose that ATP, being a mediator of sympathetic vasoconstriction, participates in baroreceptor-induced stabilization of MAP level. (C) 1998 Elsevier Science B.V. All rights reserved.
- Добавил в систему: Тарасова Ольга Сергеевна