Linear and Non-Linear Optical Imaging of Cancer Cells with Silicon Nanoparticlesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 декабря 2016 г.
Аннотация:New approaches for visualisation of silicon nanoparticles (SiNPs) in cancer cells are realised
by means of the linear and nonlinear optics in vitro. Aqueous colloidal solutions of SiNPs with sizes
of about 10–40 nm obtained by ultrasound grinding of silicon nanowires were introduced into breast
cancer cells (MCF-7 cell line). Further, the time-varying nanoparticles enclosed in cell structures
were visualised by high-resolution structured illumination microscopy (HR-SIM) and micro-Raman
spectroscopy. Additionally, the nonlinear optical methods of two-photon excited fluorescence (TPEF)
and coherent anti-Stokes Raman scattering (CARS) with infrared laser excitation were applied to
study the localisation of SiNPs in cells. Advantages of the nonlinear methods, such as rapid imaging,
which prevents cells from overheating and larger penetration depth compared to the single-photon
excited HR-SIM, are discussed. The obtained results reveal new perspectives of the multimodal
visualisation and precise detection of the uptake of biodegradable non-toxic SiNPs by cancer cells
and they are discussed in view of future applications for the optical diagnostics of cancer tumours.