Hypoxic Adaptation of Mitochondrial Metabolism in Rat Cerebellum Decreases in Pregnancyстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 7 июля 2020 г.
Аннотация:Abstract: Function of brain amino acids as neurotransmitters or their precursors implies changes inthe amino acid levels and/or metabolism in response to physiological and environmental challenges.Modelling such challenges by pregnancy and/or hypoxia, we characterize the amino acid pool in therat cerebellum, quantifying the levels and correlations of 15 amino acids and activity of 2-oxoglutaratedehydrogenase complex (OGDHC). The parameters are systemic indicators of metabolism becauseOGDHC limits the flux through mitochondrial TCA cycle, where amino acids are degraded and theirprecursors synthesized. Compared to non-pregnant state, pregnancy increases the cerebellar contentof glutamate and tryptophan, decreasing interdependence between the quantified components ofamino acid metabolism. In response to hypoxia, the dependence of cerebellar amino acid pool onOGDHC and the average levels of arginine, glutamate, lysine, methionine, serine, phenylalanine, andtryptophan increase in non-pregnant rats only. This is accompanied by a higher hypoxic resistanceof the non-pregnant vs. pregnant rats, pointing to adaptive significance of the hypoxia-inducedchanges in the cerebellar amino acid metabolism. These adaptive mechanisms are not effective in thepregnancy-changed metabolic network. Thus, the cerebellar amino acid levels and OGDHC activityprovide sensitive markers of the physiology-dependent organization of metabolic network and itsstress adaptations.