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Novel biomarkers in cancer: The whole is greater than the sum of its partsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 октября 2017 г.
- Авторы: Samatov TR, Galatenko VV, Block A., Shkurnikov MY, Tonevitsky AG, Schumacher U.
- Журнал: Seminars in Cancer Biology
- Том: 45
- Год издания: 2017
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 50
- Последняя страница: 57
- DOI: 10.1016/j.semcancer.2016.09.002
- Аннотация: The major issues hampering progress in the treatment of cancer patients are distant metastases and drug resistance to chemotherapy. Metastasis formation is a very complex process, and looking at gene signatures alone is not enough to get deep insight into it. This paper reviews traditional and novel approaches to identify gene signature biomarkers and intratumoural fluid pressure both as a novel way of creating predictive markers and as an obstacle to cancer therapy. Finally recently developed in vitro systems to predict the response of individual patient derived cancer explants to chemotherapy are discussed.
- Добавил в систему: Галатенко Владимир Владимирович