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Nuclear receptors: nomenclature, ligands, mechanisms of their effects on gene expressionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 октября 2013 г.
- Автор: Smirnov A.N.
- Журнал: Biochemistry (Moscow)
- Том: 67
- Номер: 9
- Год издания: 2002
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 957
- Последняя страница: 977
- Аннотация: Nuclear receptors are DNA binding transcription factors possessing conservative domain organization. Their activity is regulated by lipophilic ligands, phosphorylation, and by interactions with other proteins. This review highlights the nomenclature of 1999 for human nuclear receptors and the ligand structure and domain organization of these receptors. The review also summarizes recent data on the structure of hormone response elements of specific genes, the structure-functional organization of receptor co-regulators (coactivators and corepressors). They mediate their effects on transcription via two main mechanisms: chromatin remodeling and the effect on the main transcriptional factors. Some attention is focused on specific features of signal transduction at negative hormone-response elements, regulation of receptor activity via phosphorylation, mechanisms of receptor cycle termination, and on physiological and biochemical properties of certain groups of receptors and processes that they regulate.
- Добавил в систему: Смирнов Александр Николаевич