The effect of shear stress reduction on endothelial cells: A microfluidic study of the actin cytoskeleton

Авторы: Inglebert M., Locatelli L., Tsvirkun D., Sinha P., Maier J.A., Misbah C., Bureau L.
Журнал: Biomicrofluidics
Том: 14
Год издания: 2020
Издательство: AIP Publishing
Местоположение издательства: United States
DOI: 10.1063/1.5143391
Аннотация: Reduced blood flow, as occurring in ischemia or resulting from exposure tomicrogravity such as encountered in space flights, induces a decrease in thelevel of shear stress sensed by the endothelial cells forming the inner part ofblood vessels. In the present study, we use a microvasculature-on-a-chip devicein order to investigate in vitro the effect of such a reduction in shear stress onshear-adapted endothelial cells. We find that, within one hour of expositionto reduced wall shear stress, human umbilical vein endothelial cells undergo areorganization of their actin skeleton, with a decrease in the number of stressfibers and actin being recruited into the cells’ peripheral band, indicating afairly fast change in cells’ phenotype due to altered flow.
Добавил в систему: Цвиркун Дарья Викторовна

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