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In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigationsстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 12 августа 2020 г.
- Авторы: Goldberg M.A., Krohicheva P.A., Fomin A.S., Khairutdinova D.R., Antonova O.S., Baikin A.S., Smirnov V.V., Fomina A.A., Leonov A.V., Mikheev I.V., Sergeeva N.S., Akhmedova S.A., Barinov S.M., Komlev V.S.
- Журнал: Bioactive Materials
- Том: 5
- Номер: 3
- Год издания: 2020
- Издательство: KeAi Communications Co., Ltd
- Местоположение издательства: Beijing, China
- Первая страница: 644
- Последняя страница: 658
- DOI: 10.1016/j.bioactmat.2020.03.011
- Аннотация: Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded. Nevertheless, they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate. Struvite (MgNH4PO4) -based cements, which grew in popularity in recent years, despite their neutral pH and acceptable mechanical performance, release undesirable NH4+ ions during their resorption. This issue could be avoided by replacement of ammonia ions in the cement liquid with sodium, however, such cements have a pH values of 9–10, leading to cytotoxicity. Thus, the main goal of this investigation is to optimize the composition of cements to achieve the combination of desirable properties: neutral pH, sufficient mechanical properties, and the absence of cytotoxicity, applying Na2HPO4-based cement liquid. For this purpose, cement powders precursors in the CaO–MgO–P2O5 system were synthesized by one-pot process in a wide composition range, and their properties were investigated. The optimal performance was observed for the cements with (Ca + Mg)/P ratio of 1.67, which are characterized by newberyite phase formation during setting reaction, pH values close to 7, sufficient compressive strength up to 22 ± 3 MPa (for 20 mol.% of Mg), dense microstructure and adequate matrix properties of the surface. This set of features make those materials promising candidates for medical applications.
- Добавил в систему: Михеев Иван Владимирович
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