NETosis: molecular mechanisms, role in physiology and pathology

Vorobjeva, N.; Chernyak, B.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 декабря 2020 г.

Авторы: Vorobjeva NV, Chernyak BV
Журнал: Biochemistry (Moscow)
Том: 85
Номер: 10
Год издания: 2020
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1178
Последняя страница: 1190
Оригинальные версии: НЕТоз: молекулярные механизмы, роль в физиологии и патологии
DOI: 10.1134/S0006297920100065
Аннотация: NETosis is a program for formation of neutrophil extracellular traps (NETs), which consist of modified chromatin decorated with bactericidal proteins from granules and cytoplasm. Various pathogens, antibodies and immune complexes, cytokines, microcrystals, and other physiological stimuli can cause NETosis. Induction of NETosis depends on reactive oxygen species (ROS), the main source of which is NADPH oxidase. Activation of NADPH oxidase depends on an increase in the concentration of Ca2+ in the cytoplasm and in some cases on the generation of ROS in mitochondria. NETosis includes the release of the granule components into the cytosol, the modification of histones leading to chromatin decondensation, destruction of the nuclear membrane, as well as formation of pores in the plasma membrane. In this review, the basic mechanisms of NETosis, as well as its role in the pathogenesis of some diseases including COVID-19 are discussed.
Добавил в систему: Воробьева Нина Викторовна

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NETosis: molecular mechanisms, role in physiology and pathologyстатья

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