Magnetic levitational bioassembly of 3D tissue construct in space

Parfenov, V.A.; Khesuani, Y.D.; Petrov, S.V.; Karalkin, P.A.; Koudan, E.V.; Nezhurina, E.K.; Pereira, F.D.; Krokhmal, A.A.; Gryadunova, A.A.; Bulanova, E.A.; Vakhrushev, I.V.; Babichenko, I.I.; Kasyanov, V.; Petrov, O.F.; Vasiliev, M.M.; Brakke, K.; Belousov, S.I.; Grigoriev, T.E.; Osidak, E.O.; Rossiyskaya, E.I.; Buravkova, L.B.; Kononenko, O.D.; Demirci, U.; Mironov, V.A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 сентября 2020 г.

Авторы: Parfenov Vladislav A., Khesuani Yusef D., Petrov Stanislav V., Karalkin Pavel A., Koudan Elizaveta V., Nezhurina Elizaveta K., Pereira Frederico DAS, Krokhmal Alisa A., Gryadunova Anna A., Bulanova Elena A., Vakhrushev Igor V., Babichenko Igor I., Kasyanov Vladimir, Petrov Oleg F., Vasiliev Mikhail M., Brakke Kenn, Belousov Sergei I., Grigoriev Timofei E., Osidak Egor O., Rossiyskaya Ekaterina I., Buravkova Ludmila B., Kononenko Oleg D., Demirci Utkan, Mironov Vladimir A.
Журнал: Science Advances
Том: 6
Номер: 29
Год издания: 2020
Номер статьи: eaba4174
DOI: 10.1126/sciadv.aba4174
Аннотация: Magnetic levitational bioassembly of three-dimensional (3D) tissue constructs represents a rapidly emerging scaffold- and label-free approach and alternative conceptual advance in tissue engineering. The magnetic bioassembler has been designed, developed, and certified for life space research. To the best of our knowledge, 3D tissue constructs have been biofabricated for the first time in space under microgravity from tissue spheroids consisting of human chondrocytes. Bioassembly and sequential tissue spheroid fusion presented a good agreement with developed predictive mathematical models and computer simulations. Tissue constructs demonstrated good viability and advanced stages of tissue spheroid fusion process. Thus, our data strongly suggest that scaffold-free formative biofabrication using magnetic fields is a feasible alternative to traditional scaffold-based approaches, hinting a new perspective avenue of research that could significantly advance tissue engineering. Magnetic levitational bioassembly in space can also advance space life science and space regenerative medicine.
Добавил в систему: Крохмаль Алиса Александровна

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