A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioningстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 19 июля 2013 г.
Аннотация:Hypoxic preconditioning is thought to rely on gene products regulated by
hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene
cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for
neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using
wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of
wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased cell death
after hypoxia/aglycemia. Moreover, deferoxamine-induced endogenous tolerance did
not involve p21(WAF1/CIP1) expression in cortical neurons. Our data suggest that
balanced expression and potentially posttranslational regulation of
p21(WAF1/CIP1) is required for hypoxic preconditioning.