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Regulatory mechanisms of proton-translocating F(O)F (1)-ATP synthaseстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
- Авторы: Feniouk B.A., Yoshida M.
- Сборник: Bioenergetics
- Серия: Results and Problems in Cell Differentiation
- Том: 45
- Год издания: 2008
- Место издания: Springer Berlin Heidelberg
- Первая страница: 279
- Последняя страница: 308
- DOI: 10.1007/400_2007_043
- Аннотация: H(+)-F(O)F(1)-ATP synthase catalyzes synthesis of ATP from ADP and inorganic phosphate using the energy of transmembrane electrochemical potential difference of proton (deltamu(H)(+). The enzyme can also generate this potential difference by working as an ATP-driven proton pump. Several regulatory mechanisms are known to suppress the ATPase activity of F(O)F(1): 1. Non-competitive inhibition by MgADP, a feature shared by F(O)F(1) from bacteria, chloroplasts and mitochondria 2. Inhibition by subunit epsilon in chloroplast and bacterial enzyme 3. Inhibition upon oxidation of two cysteines in subunit gamma in chloroplast F(O)F(1) 4. Inhibition by an additional regulatory protein (IF(1)) in mitochondrial enzyme In this review we summarize the information available on these regulatory mechanisms and discuss possible interplay between them.
- Добавил в систему: Фенюк Борис Александрович