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Mechanisms of ischemic kidney tolerance in young and senescence-accelerated rats exposed to ischemic preconditioning or calorie restrictionтезисы доклада
- Авторы: Egor Plotnikov, Nadezda Andrianova, Stanislovas Jankauskas, Irina Pevzner, Ljubava Zorova, Vasily Popkov, Denis Silachev, Natalia Kolosova, Dmitry Zorov
- Сборник: Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06–10 July 2020, Novosibirsk, Russia); Abstracts
- Тезисы
- Год издания: 2020
- Место издания: ICG SB RAS Novosibirsk
- Первая страница: 502
- Последняя страница: 503
- Аннотация: Calorie restriction (CR) and ischemic preconditioning (IPC) are the most efficient approaches ameliorating the severity of different pathological conditions.We investigated the protective potential of long-term calorie restriction and short ischemic preconditioning protocol in the model of acute kidney injury (AKI) in young Wistar and OXYS rats. In young rats, ischemic preconditioning, which consists of 4 cycles of ischemia and reperfusion alleviated kidney injury caused by 40-min ischemia. However, 6-month-old OXYS rats having signs of premature aging lost their ability to protect the ischemic kidney by IPC. However, CR of OXYS rats led to a significant decrease in creatinine and blood urea nitrogen levels after kidney ischemia, indicating significant protection.
- Добавил в систему: Плотников Егор Юрьевич