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MRI study of early and late consequences of prolonged seizures and effects of ginsenosides of ginseng on lithium-pilocarpine model of status epilepticusтезисы доклада
- Авторы: Suleymanova E., Gulyaev M., Chepurnova N.
- Сборник: 8th IBRO World Congress of Neuroscience, Florence, Italy
- Тезисы
- Год издания: 2011
- Первая страница: B384
- Аннотация: Convulsive status epilepticus (SE) is a life-threatening condition when epileptic seizures last for more than 30 minutes. Prolonged seizure activity leads to injuries of hippocampus and associated structures with subsequent development of chronic epilepsy. We studied early and late changes in rat brain on lithium-pilocarpine model of status epilepticus, and evaluated the effect of ginsenosides of ginseng administration which possibly can demonstrate a neuroprotective effect. Magnetic resonance imaging (MRI) is a non-invasive method which allows performing in vivo studies of the development of brain damage. To study the consequences of SE and ginsenosides effects, high resolution T2-weighted images were obtained. T2-mapping was performed to evaluate T2 coefficients in hippocampus, enthorinal and piriform cortices, neocortex and amygdala. Hippocampal volume was also evaluated. The study was performed 2, 7 and 30 days after SE. 2 days after SE induced by pilocarpine, the increase of T2 signal was found in hippocampus, enthorinal and piriform cortices, and amygdala in comparison with intact rats. 7 days after SE the changes became less pronounced. The patterns of brain damage in rats after SE varied considerably. Chronic but not single administration of ginsenosides attenuated changes revealed by MRI study of rat brain. 30 days after SE a significant reduction of hippocampal volume was found in saline-treated rats, and in rats treated with ginsenosides during 30 days the reduction of hippocampal volume was less pronounced. Early changes found by MRI study of brain after SE correlated with late consequences of SE. Thus MRI can be a useful method of early prediction of SE pathologic consequences and estimation of efficiency of neuroprotectors. The MRI study of rat brain showed that chronic administration of ginsenosides of ginseng attenuated the severity of brain damage after SE.
- Добавил в систему: Гуляев Михаил Владимирович