Subjective impressions of stable patients with paranoid schizophrenia after adding to antipsychotic treatment anticholinesterase agent

Morozova, M.; Rupchev, G.

Авторы: Morozova M., Rupchev G.
Журнал: European Psychiatry
Том: 63
Номер: S
Год издания: 2020
Издательство: Cambridge University Press
Местоположение издательства: United Kingdom
Первая страница: 249
Последняя страница: 250
Номер статьи: EPP1111
DOI: 10.1192/j.eurpsy.2020.5
Аннотация: Introduction: Discrepancy between objective data and subjectiveexperience is rather often in patients with schizophrenia. Especiallyit concerns the situation when the treatment target is the negativedomain of symptoms. In the previous study of ipidacrine – nonselective anticholinergic agent, in patients with schizophrenia andprominent cognitive deterioration, we’ve seen significant positivechanges in Positive and negative symptoms scale (PANSS) scores,assessing emotions (Morozova et al, 2008).Objectives: Subjective response of stable patients with paranoidschizophrenia after adding ipidacrine to basic antipsychotictreatment.Methods: 26 patients (ICD10-F 20.0) were included into the8 weeks open-labeled study of low dose (20 mg daily) of ipidacrinedaily, added to basic antipsychotic treatment (males – 50%),PANSS at the beginning 75,8 (SD -12,4). The instruments ofassessment: PANSS, Brief Assessment of cognition in Schizophrenia (BACS), self-report of patients.Results: 21 completed the protocol. There were significant changesin PANSS negative score and BACS T-score and no changes positive score. There was no correlation between improvement innegative and BACS score. Patients reported the following: “betterunderstand humor”, ”could start to visit dentist”, “ easier to communicate, not so constrained” , “more alert”, “feel more comfortinside”, “better time-planning, less mess in my life”, “my mind isnot foggy anymore”, “my thinking goes smoothly”, “ can plan andfulfill plans”,“can remember, what I ate on breakfast”,“ don’t forgetto take my medication anymore”.Conclusions: The patients feel the effects of low dose of ipidacrineas integrally improvement of wellbeing, due changes in individuallyimportant field of psychic.Keywords: schizophrenia; negative symptoms; add-on treatment;ipidacrine
Добавил в систему: Рупчев Георгий Евгеньевич

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ЦЭМИ РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ЦЭМИ РАН

Subjective impressions of stable patients with paranoid schizophrenia after adding to antipsychotic treatment anticholinesterase agentстатья Тезисы Исследовательская статья Краткое сообщение Электронная публикация

Прикрепленные файлы