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A Cross-Sectional Study of the Gut Microbiota Composition in Moscow Long-Liversстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 сентября 2020 г.
- Авторы: Kashtanova Daria A., Klimenko Nataliya S., Strazhesko Irina D., Starikova Elizaveta V., Glushchenko Oksana E., Gudkov Denis A., Tkacheva Olga N.
- Журнал: Microorganisms
- Том: 8
- Номер: 8
- Год издания: 2020
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1162
- Последняя страница: 1162
- DOI: 10.3390/microorganisms8081162
- Аннотация: Abstract: The aim was to assess the gut microbiota of long-livers from Moscow. This study includedtwo groups of patients who signed their consent to participate. The group of long-livers (LL) included20 participants aged 97–100 years (4 men and 16 women). The second group included 22 participantsaged 60–76 years (6 men) without clinical manifestations of chronic diseases (healthy elderly).Gut microbiota was studied by 16S rRNA sequencing. Long-livers underwent a complex geriatricassessment as well as expanded blood biochemistry. Gut microbiota composition in the cohorts wasalso compared with microbiome in long-livers from Japan and Italy. Russian long-livers’ microbiomecontained more beneficial bacteria than healthy elderly including Ruminococcaceae, Christensenellaceae,Lactobacillaceae families. Conditional pathogens like Veillonellaceae, Mogibacteriaceae, Alcaligenaceae,Peptococcaceae, Peptostreptococcaceae were more abundant in the healthy elderly. Compared withItalian and Japanese microbiome LL, the Russian LL appeared to be more similar to the Italian cohort.Bifidobacterium/Coprococcus and Faecalibacterium/Coprococcus balances were associated with femoral andcarotid intima–media thickness, respectively. Bifidobacterium/Coriobacteriaceae balance was assessedwith the folic acid level and Faecalibacterium/Coriobacteriaceae_u the with Mini Nutritional Assessmentscore. Long-livers’ microbiome appeared to be unexpectedly balanced. The high representation ofbeneficial bacteria in long-livers may prevent them from low-grade inflammation and thus protectthem from the development of atherosclerosis and other aging-associated conditions.
- Добавил в систему: Стражеско Ирина Дмитриевна