Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Andrianova, N.V.; Zorova, L.D.; Pevzner, I.B.; Popkov, V.A.; Chernikov, V.P.; Silachev, D.N.; Plotnikov, E.Y.; Zorov, D.B.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 октября 2020 г.

Авторы: Andrianova Nadezda V., Zorova Ljubava D., Pevzner Irina B., Popkov Vasily A., Chernikov Valery P., Silachev Denis N., Plotnikov Egor Y., Zorov Dmitry B.
Журнал: AGING-US
Том: 12
Год издания: 2020
Первая страница: 1
Последняя страница: 23
DOI: 10.18632/aging.103960
Аннотация: Dietary restriction (DR) is the strategy ameliorating the morbidity of various pathologies, including age-associated diseases. Acute kidney injury (AKI) remains a problem for the elderly with DR being a promising approach for diminishing its consequences. We evaluated the possible nephroprotective potential of short-term DR in young and old rats. DR in young rats resulted in pronounced beneficial effects normalizing lipid metabolism (triglycerides concentration, adiponectin level) activating autophagic-lysosomal system evaluated by LC3II/LC3I ratio, LAMP1, p62/SQSTM1 levels, and LysoTracker Green staining. DR had a remarkable recovering effect on mitochondrial structure and functions including regaining of mitochondrial membrane potential, the elevation of SIRT-3, PGC-1α, Bcl-XL levels and partial restoration of ultrastructure. The beneficial effects of DR resulted in the mitigation of oxidative stress including a decrease in levels of protein carbonylation and lipid peroxidation. Aging led to decreased activity of autophagy, elevated oxidative stress and impaired kidney regenerative capacity. Eventually, in old rats, even 8-week DR was not able to ameliorate AKI, but it caused some rejuvenating effects including elevation of mitochondrial membrane potential and Bcl-XL levels, as well as lowered severity of the oxidative stress. Thus, the age-associated decline of protective signaling demands extended DR to achieve nephroprotective potential in old animals.
Добавил в систему: Андрианова Надежда Владимировна

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Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old ratsстатья Исследовательская статья

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