Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function and Utility as Drug Targets

Borisov, V.B.; Siletsky, S.A.; Paiardini, A.; Hoogewijs, D.; Forte, E.; Giuffre, A.; Poole, R.K.

Авторы: Borisov Vitaliy B., Siletsky Sergey A., Paiardini Alessandro, Hoogewijs David, Forte E., Giuffre Alessandro, Poole Robert K.
Журнал: Antioxidants and Redox Signaling
Том: 34
Номер: 16
Год издания: 2021
Издательство: Mary Ann Liebert Inc.
Местоположение издательства: United States
Первая страница: 1280
Последняя страница: 1318
DOI: 10.1089/ars.2020.8039
Аннотация: Significance. Cytochrome bd is a ubiquinol:oxygen-oxidoreductase of many prokaryotic respiratory chains with a unique structure and functional characteristics. Its primary role is to couple the reduction of molecular oxygen, even at sub-micromolar concentrations, to water with the generation of a proton motive force used for ATP production. Cytochrome bd is found in many bacterial pathogens and, surprisingly, in bacteria formally denoted as anaerobes. It endows bacteria with resistance to various stressors and is a potential drug target.Recent Advances. We summarize recent advances in the biochemistry, structure and physiological functions of cytochrome bd in the light of exciting new three-dimensional structures of the oxidase. The newly discovered roles of cytochrome bd in contributing to bacterial protection against H2O2, NO, peroxynitrite and H2S are assessed.Critical Issues. Fundamental questions remain regarding the precise delineation of electron flow within this multi-haem oxidase and how the extraordinarily high affinity for oxygen is accomplished, while endowing bacteria with resistance to other small ligands.Future Directions. It is clear that cytochrome bd is unique in its ability to confer resistance to toxic small molecules, a property that is significant for understanding the propensity of pathogens to possess this oxidase. Since cytochrome bd is a uniquely bacterial enzyme, future research should focus on harnessing fundamental knowledge of its structure and function to the development of novel and effective antibacterial agents.
Добавил в систему: Борисов Виталий Борисович

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Bacterial Oxidases of the Cytochrome bd Family: Redox Enzymes of Unique Structure, Function and Utility as Drug Targetsстатья

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