Аннотация:Modern medicine is looking for new and efficient preparations for therapeutic such illnesses like rheumatoid arthritis or Crohn's disease. Since 1948 medicine word got glucocorticoid preparations based on adrenal cortex hormones. Researchers Hench and Kendall along with Tadeusz Reichstein even got a Nobel Prize(GCs) for “for their discoveries relating to the hormones of the adrenal cortex, their structure and biological effects.” These cures got a treatment revolution in the therapeutic of hard diseases, but possible unwanted side effects have often become the reasons for discussions. So the author of the present article deals with a survey of conclusions, based on results obtained by the European League Against Rheumatism — EULAR. The resumes of this research group are based on the conclusions of patients and medical experts based on analyzing huge amounts of literature. It has been noted that the development of adverse effects depends on specifics therapy (duration, and dosage) and specific person factors peculiar to every patient. So the positive evaluation of the GCs-therapy depends on the correlation of the expected treatment effects and developed adverse effects. It can be achieved by checking the elongation of treatment-time, dosage, and personal features of the patients. All of these parameters can be connected due to respect to actual knowledge and recommendations, and its correct usages in practice.