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AVPR1A main effect and OXTR-by-environment interplay in individual differences in depression levelстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 декабря 2020 г.
- Авторы: Kazantseva A., Davydova Yu, Enikeeva R., Lobaskova M., Mustafin R., Malykh S., Takhirova Z., Khusnutdinova E.
- Журнал: Heliyon
- Том: 6
- Номер: 10
- Год издания: 2020
- Издательство: Elsevier Science Publishing Company, Inc.
- Местоположение издательства: Нидерланды
- Первая страница: 1
- Последняя страница: 13
- Номер статьи: e05240
- DOI: 10.1016/j.heliyon.2020.e05240
- Аннотация: Background: Multiple studies of depression indicated a significant role of gene-by-environment interactions; however, they are mainly limited to the examination of modulating effect of recent stressful life events. Other environmental factors occurring at different stages of ante- and postnatal development may affect the association between multiple genes and depression. The study aimed to analyze the main and haplotype-based effect of serotonergic system and HPA-axis gene polymorphisms on depression and to detect gene-by-environment interaction models explaining individual variance in depression in mentally healthy young adults from Russia.Methods: Depression score was assessed using Beck Depression Inventory (BDI) in 623 healthy individuals (81% women; 17-25 years) of Caucasian origin (Russians, Tatars, Udmurts) from Russia. The main- and gene-based effects of 12 SNPs in SLC6A4 (5-HTTLPR, rs1042173), HTR2A (rs7322347), OXTR (rs7632287, rs2254298, rs13316193, rs53576, rs2228485, rs237911), AVPR1A (rs3803107, rs1042615), and AVPR1B (rs33911258) genes, and gene-by-environment interactions were tested with linear regression models (PLINK v.1.9) adjusted for multiple comparisons.Results: We observed ethnicity-specific main effect of the AVPR1A rs3803107 (P ¼ 0.003; PFDR ¼ 0.047) and gene based effect of the OXTR gene (Р ¼ 0.005; Pperm ¼ 0.034) on BDI-measured depression, and modifying effect of paternal care on OXTR rs53576 (P ¼ 0.004; PFDR ¼ 0.012) and birth order on OXTR rs237911 (P ¼ 0.006; PFDR ¼ 0.018) association with depression level.Limitations: A hypothesis driven candidate gene approach, which examined a limited number of genetic variants in a moderately large sample, was used.Conclusions: Our preliminary findings indicate that familial environment may play a permissive role modulating the manifestation of OXTR-based depression variance in mentally healthy subjects.
- Добавил в систему: Малых Сергей Борисович