Аннотация:We consider the Lorentz space with mixed norm of periodic functions of many variables and Nikol'skii -- Besov type classes of the generalized mixed smoothness. We have obtained estimates of the best approximation by trigonometric polynomials with the harmonics from the hyperbolic crosses of functions from Nikol'skii-Besov's type classes of the generalized mixed smoothness in the Lorentz space with the mixed norm.