Effect of cross-linking on the inclusion complex formation of derivatized β-cyclodextrins with small-molecule drug Moxifloxacin

Skuredina, A.A.; Le-Deygen, I.M.; Belogurova, N.G.; Kudryashova, E.V.

Авторы: Skuredina A.A., Le-Deygen I.M., Belogurova N.G., Kudryashova E.V.
Журнал: Carbohydrate Research
Год издания: 2020
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 108183
DOI: 10.1016/j.carres.2020.108183
Аннотация: Derivatized β-cyclodextrins (CDs), cyclic oligomers of glucose with inner cavity, are able to form the inclusion complex with many poorly soluble lipophilic organic molecules, including drugs, thus improving their solubility in aqueous solutions and drug bioavailability. Here, we have studied the effect of cross-linking of derivatized CDs with different substituent nature, on their binding with antibacterial drug moxifloxacin (MF) which served as a model small molecule drug. Cross-linking of derivatized CDs with 1,6-hexamethylene diisocyanate (HMD) yielded 100-200 nm nanoparticles with distinct binding properties, strongly depending on the nature of the CD substituent, degree of oligomerization, and the nanoparticle’s charge. Interestingly, substituent that improved MF binding to monomeric CDs the most (methyl moiety), had reverse effect in the case of cross-linked CD. Whereas the substituent that had only limited effect on the monomeric CD (sulfobutyl ether moiety), improved binding of cross-linked CD by almost two orders of magnitude. Further, we show that the cross-linked CD complexes with MF perform better in vitro antibacterial assay on E.coli, compared to both free MF and monomeric CD-MF. Overall, this data indicates the potential utility of CD cross-linking and derivatization to develop small molecule drug formulations with improved pharmacological properties.
Добавил в систему: Кудряшова Елена Вадимовна

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Effect of cross-linking on the inclusion complex formation of derivatized β-cyclodextrins with small-molecule drug Moxifloxacinстатья

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