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Contribution of Monovalent (Na+ and K+) and Divalent (Ca2+) Ions to the Mechanisms of Synaptic Plasticityстатья
Дата последнего поиска статьи во внешних источниках: 4 августа 2021 г.
- Авторы: Smolyaninova L.V., Shiyan A.A., Maksimov G.V., Orlov S.N.
- Журнал: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology
- Том: 15
- Номер: 1
- Год издания: 2021
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1
- Последняя страница: 20
- Аннотация: The review presents the mechanisms of participation of ions (Na+, K+, and Ca2+) in the processesof synaptic plasticity in the postsynaptic neuron during long-term potentiation and long-term depression. Itis assumed that the main participants are AMPA and NMDA receptors, voltage-dependent Na+, K+, Ca2+channels, Ca2+ and Na+-activated K+ channels, ATP-sensitive K+ channels, and Ca2+ channels of the endoplasmic reticulum. The review provides their molecular characteristics and discusses their role in long-termpotentiation and long-term depression. The significance of changes in the intracellular ratio [Na+]i/[K+]i andCa2+-dependent mechanism are considered for the first time from the signal formation to the level of geneexpression. We believe that additional research is needed to identify a subset of neuronal genes whose differential expression contributes to synaptic plasticity, which is implemented with the participation of[Na+]i/[K+]i-sensitive Ca2+-independent “excitation–transcription coupling” mechanism.
- Добавил в систему: Смольянинова Лариса Викторовна