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Effects of lysine-containing peptides treatment on FXIII activity and fibrinogen level of metabolic disordersстатья
Дата последнего поиска статьи во внешних источниках: 4 августа 2021 г.
- Авторы: Shubina T., Obergan T.
- Журнал: Research and Practice in Thrombosis and Haemostasis
- Том: 4
- Год издания: 2020
- Издательство: John Wiley & Sons
- Местоположение издательства: Hoboken, NJ, United States
- Первая страница: 350
- Последняя страница: 351
- Номер статьи: PB0716
- Аннотация: Aims: To evaluate the treatment effects of glyproline peptides RKKRPGP and KRKPGP on the fibrinogen levels and the blood coagulation Factor XIII activity in animals with experimental metabolic syndrome.It was found that RKKRPGP and KRKPGP-treatment (0.1 mg/kg body weight, intranasally, once daily, 7 days) led to a decrease in the FXIII activity and significant decrease in the fibrinogen concentration (only KRKPGP). So, the studied peptides had an affect the fibrinolysis processes in metabolic disorders due to their ability to reduce the activity of FXIII and fibrinogen levels (only KRKPGP), which can be useful in the fight against metabolic syndrome complications.
- Добавил в систему: Оберган Тамара Юрьевна