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The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patchстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 декабря 2020 г.
- Авторы: Yuliya Kan, Cvjetinovic Julijana, Statnik Eugene S., Ryazantsev Sergey V., Anisimova Natalia Yu, Kiselevskiy Mikhail V., Salimon Alexey I., Maksimkin Alexey V., Korsunsky Alexander M.
- Журнал: Materials Today Communications
- Том: 24
- Год издания: 2020
- Издательство: Elsevier Ltd.
- Местоположение издательства: Amsterdam, Netherlands
- Номер статьи: 101052
- DOI: 10.1016/j.mtcomm.2020.101052
- Аннотация: A layered hybrid implant was designed and fabricated for the surgical replacement of worn cartilage to meet the complex requirements of biocompatibility and mechanics. The natural hierarchical structure was purposefully mimicked to improve the implant performance and integration. The hybrid was fabricated using three components: processed collagen gel, hydroxyapatite (HAp) powder and ultra-high molecular weight polyethylene (UHMWPE) in bulk and sponge form. The fabrication included hot molding, sacrificial templating, infusion, and freeze-casting stages. The hybrid had a porous transition layer made of porous UHMWPE impregnated with collagen by means of infusion. SEM and FTIR analyses confirmed successful collagen impregnation of porous UHMWPE. The morphology of transition layer was selected and produced to provide the UHMWPE pore size distribution in a range ∼50–150 μm that is favorable for the osseointegration by osteoblast proliferation. Biocompatibility tests were carried out in vitro. The index of red blood cells hemolysis showed 0.6 % after 4 h of co-incubation that proved excellent biocompatibility of the fabricated UHMWPE-Collagen-HAp hybrid.
- Добавил в систему: Рязанцев Сергей Викторович