|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ЦЭМИ РАН |
||
SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptorsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 февраля 2021 г.
- Авторы: Shomuradova AS, Vagida MS, Sheetikov SA, Zornikova KV, Kiryukhin D., Titov A., Peshkova IO, Khmelevskaya A., Dianov DV, Malasheva M., Shmelev A., Serdyuk Y., Bagaev DV, Pivnyuk A., Shcherbinin DS, Maleeva AV, Shakirova NT, Pilunov A., Malko DB, Khamaganova EG, Biderman B., Ivanov A., Shugay M., Efimov GA
- Журнал: Immunity
- Том: 53
- Номер: 6
- Год издания: 2020
- Издательство: Cell Press
- Местоположение издательства: United States
- Первая страница: 1245
- Последняя страница: 1257
- DOI: 10.1016/j.immuni.2020.11.004
- Аннотация: Understanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response. Their probable exposure to the virus resulted in either asymptomatic infection without antibody secretion or activation of preexisting immunity. In convalescent patients, we observed a public and diverse T cell response to SARS-CoV-2 epitopes, revealing T cell receptor (TCR) motifs with germline-encoded features. Bulk CD4+ and CD8+ T cell responses to the spike protein were mediated by groups of homologous TCRs, some of them shared across multiple donors. Overall, our results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity.
- Добавил в систему: Шитиков Савелий Андреевич