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Clonal relationship of marginal zone lymphoma and diffuse large B-cell lymphoma in Sjogren's syndrome patients: case series study and review of the literatureстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 декабря 2020 г.
- Авторы: Gorodetskiy Vadim Romanovich, Probatova Natalya Alexandrovna, Radenska-Lopovok Stefka Gospodinova, Ryzhikova Natalya Valerievna, Sidorova Yulia Vladimirovna, Sudarikov Andrey Borisovich
- Журнал: Rheumatology International
- Том: 40
- Номер: 3
- Год издания: 2019
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 499
- Последняя страница: 506
- DOI: 10.1007/s00296-019-04470-x
- Аннотация: AbstractThe occurrence of difuse large B-cell lymphoma (DLBCL) in the course of Sjogren’s syndrome (SS) is considered to beequally related either to the development of DLBCL de novo or to the transformation from marginal zone lymphoma (MZL).However, the question of possible clonal relationship between MZL and DLBCL in the group of SS patients remains open.Here we present the data concerning 194 patients with lymphoma complicated SS followed up at Nasonova Research Insti-tute of Rheumatology during the last 22 years. Molecular analysis of tumor cells was performed for 6 SS patients who haddeveloped both MZL and DLBCL. To assess clonal relationship between each of the tumor pairs immunoglobulin heavychain (IGH) gene rearrangements were identifed according BIOMED-2 protocol by means of multiplex polymerase chainreaction followed by GeneScan fragment analysis. Despite diferent localization MZL and DLBCL were clonally related infve tumor pairs. The median time to transformation was 11 months (range 0–78 months). MZL and DLBCL were clonallyrelated in most cases from our cohort of SS patients. No statistically signifcant diference in survival between patients withDLBCL transformed from MZL and patients with de novo DLBCL was found in the cohort of SS patients investigated.
- Добавил в систему: Судариков Андрей Борисович