The Emericellipsins A-E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungiстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 9 апреля 2021 г.
Аннотация:Novel antimicrobial peptides with antifungal and cytotoxic activity were derived fromthe alkalophilic fungus Emericellopsis alkalina VKPM F1428. We previously reported that this strainproduced emericellipsin A (EmiA), which has strong antifungal and cytotoxic properties. Furtheranalyses of the metabolites obtained under a special alkaline medium resulted in the isolationof four new homologous (Emi B-E). In this work, we report the complete primary structure anddetailed biological activity for the newly synthesized nonribosomal antimicrobial peptides calledemericellipsins B–E. The inhibitory activity of themajor compound, EmiA, against drug-resistantpathogenic fungi was similar to that of amphotericin B (AmpB). At the same time, EmiA had nohemolytic activity towards human erythrocytes. In addition, EmiA demonstrated low cytotoxicactivity towards the normal HPF line, but possessed cancer selectivity to the K-562 and HCT-116cell lines. Emericillipsins from the alkalophilic fungus Emericellopsis alkaline are promising treatmentalternatives to licensed antifungal drugs for invasive mycosis therapy, especially for multidrug resistant aspergillosis and cryptococcosis.