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Classical Model of 6-Hydroxydopamine–Induced Parkinsonism in Rats is Characterized by Unilateral Lesion of Brain Mesolimbic Systemстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 сентября 2021 г.
- Авторы: Stavrovskayaa A.V., Berezhnoya D.S., Voronkov D.N., Stvolinski S.L., Abaimov D.A., Olshanski A.S., Gushchina A.S., Yamshchikova N.G., Fedorovaa T.N.
- Журнал: Neurochemical Journal
- Том: 37
- Номер: 3
- Год издания: 2020
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 249
- Последняя страница: 256
- DOI: 10.31857/S1027813320030103
- Аннотация: The problem of localizing lesions in the brain of rodents after administration of neurotoxic 6-hydroxidopamine (6-OHDA) is important for understanding of the mechanisms of parkinsonism progression. The present study provides the results of behavioral tests, immunohistochemistry, and measurements of dopamine (DA) level in different areas of the striatum 25 days after unilateral intranigral injection of 6-OHDA to rats. Neuronal death was observed in both pars compacta of substantia nigra and the lateral nucleus of ventral tegmental area (VTA). Detailed analysis of DA level showed a 90% decrease in the dorsal striatum and a 73% decrease in the ventral striatum only at the side ipsilateral to the toxin injection. Discovered changes in VTA are similar to the results of morphological post mortem studies of Parkinson’s disease. Previously found emotional disturbances in rats with 6-OHDA–induced Parkinson’s disease may be related to the damage in VTA shown in our study
- Добавил в систему: Бережной Даниил Сергеевич