MATHEMATICAL MODELING OF CALCIUM-DEPENDENT INSULIN SIGNALING IN HEPATOCYTES

Авторы: Tilinova O.M., Samarina E.A., Yamashev M.V., Dokukina I.V., Grachev E.A.
Сборник: The 5th International Symposium and International School for Young Scientists on “Physics, Engineering and Technologies for BioMedicine”. PROGRAMME BOOK OF ABSTRACTS
Том: 1
Тезисы
Год издания: 2020
Место издания: National Research Nuclear University MEPhI National Research Nuclear University MEPhI
Первая страница: 159
Последняя страница: 160
Аннотация: There are three major factors in intracellular calcium signaling, including, among others, the sensitivity of IP3-receptors, the endoplasmic reticulum stress, and the mitochondria-associated membranes (MAMs) (see Fig.1). However, it is still unclear which factor is more or the most important than others.Our model describes all involved players and allows us to study the individual contribution of each of the assumed factors to the development of hepatocyte insulin resistance. It is assembled from combination of well-established models of IP3-receptor dynamics and of mitochondrial impact on cytosolic Ca2+ signaling
Добавил в систему: Ямашев Михаил Владимирович

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