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The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS studyстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 июня 2021 г.
- Авторы: Mazzinari Guido, Serpa Neto Ary, Hemmes Sabrine N.T., Hedenstierna Goran, Jaber Samir, Hiesmayr Michael, Hollmann Markus W., Mills Gary H., Vidal Melo Marcos F., Pearse Rupert M., Putensen Christian, Schmid Werner, Severgnini Paolo, Wrigge Hermann, Cambronero Oscar Diaz, Ball Lorenzo, de Abreu Marcelo Gama, Pelosi Paolo, Schultz Marcus J.Alexey Gritsan, Tatyana Kapkan, Galina Gritsan, Oleg Korolkov, Alexander Kulikov, Andrey Lubnin, Alexey Ovezov, Pavel Prokoshev, Alexander Lugovoy, Natalia Anipchenko, Andrey Babayants, Irina Komissarova, Karginova Zalina, Valery Likhvantsev, Sergei Fedorov, LAS VEGAS study–investigators PROtective VEntilation NETwork Clinical Trial Network of the European Society of Anaesthesiology
- Журнал: BMC Anesthesiology
- Том: 21
- Номер: 1
- Год издания: 2021
- Издательство: BioMed Central
- Местоположение издательства: London
- Первая страница: 1
- Последняя страница: 15
- Номер статьи: 84
- DOI: 10.1186/s12871-021-01268-y
- Аннотация: Background: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time-weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events.Methods: Posthoc retrospective propensity score-weighted cohort analysis of patients undergoing open or closed abdominal surgery in the 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events.Results: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12- to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001).Conclusions: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery.Trial registration: LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223 ).
- Добавил в систему: Куликов Александр Сергеевич
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