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Caloric restriction modifies spatiotemporal calcium dynamics in mouse hippocampal astrocytesстатья Электронная публикация
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 июня 2021 г.
- Авторы: Denisov Pavel, Popov Alexander, Brazhe Alexey, Lazareva Natalia, Verkhratsky Alexei, Semyanov Alexey
- Журнал: Biochimica et Biophysica Acta - Molecular Cell Research
- Том: 1868
- Номер: 7
- Год издания: 2021
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Номер статьи: 119034
- DOI: 10.1016/j.bbamcr.2021.119034
- Аннотация: We analysed spatiotemporal properties of Ca2+ signals in protoplasmic astrocytes in the CA1 stratum radiatum of hippocampal slices from young (2–3 months old) mice housed in control conditions or exposed to a caloric restriction (CR) diet for one month. The astrocytic Ca2+ events became shorter in duration and smaller in size; they also demonstrated reduced velocity of expansion and shrinkage following CR. At the same time, Ca2+ signals in the astrocytes from the CR animals demonstrated higher amplitude and the faster rise and decay rates. These changes can be attributed to CR-induced morphological remodelling and uncoupling of astrocytes described in our previous study. CR-induced changes in the parameters of Ca2+ activity were partially reversed by inhibition of gap junctions/hemichannels with carbenoxolone (CBX). The effect of CBX on Ca2+ activity in CR-animals was unexpected because the diet already decreases gap junctional coupling in astrocytic syncytia. It may reflect the blockade of hemichannels also sensitive to this drug. Thus, CR-induced morphological remodelling of astrocytes is at least partly responsible for changes in the pattern of Ca2+ activity in the astrocytic network. How such changes in spatiotemporal Ca2+ landscape can translate into astrocytic physiology and neuron-glia interactions remains a matter for future studies.
- Добавил в систему: Браже Алексей Рудольфович