Serum Zinc, Copper, and Other Biometals Are Associated with COVID-19 Severity Markers

Skalny, A.V.; Timashev, P.S.; Aschner, M.; Aaseth, J.; Chernova, L.N.; Belyaev, V.E.; Grabeklis, A.R.; Notova, S.V.; Lobinski, R.; Tsatsakis, A.; Svistunov, A.A.; Fomin, V.V.; Tinkov, A.A.; Glybochko, P.V.

Авторы: Skalny Anatoly V., Timashev Peter S., Aschner Michael, Aaseth Jan, Chernova Lyubov N., Belyaev Vladimir E., Grabeklis Andrey R., Notova Svetlana V., Lobinski Ryszard, Tsatsakis Aristides, Svistunov Andrey A., Fomin Victor V., Tinkov Alexey A., Glybochko Peter V.
Журнал: Metabolites
Том: 11
Номер: 4
Год издания: 2021
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 244
Последняя страница: 244
DOI: 10.3390/metabo11040244
Аннотация: The objective of the present study was to evaluate of serum metal levels in COVID-19 patients with different disease severity, and to investigate the independent association between serum metal profile and markers of lung damage. The cohort of COVID-19 patients consisted of groups of subjects with mild, moderate, and severe illness, 50 examinees each. Forty-four healthy subjects of the respective age were involved in the current study as the control group. Serum metal levels were evaluated using inductively-coupled plasma mass-spectrometry. Examination of COVID-19 patients demonstrated that heart rate, respiratory rate, body temperature, C-reactive protein levels, as well as lung damage increased significantly with COVID-19 severity, whereas SpO2 decreased gradually. Increasing COVID-19 severity was also associated with a significant gradual decrease in serum Ca, Fe, Se, Zn levels as compared to controls, whereas serum Cu and especially Cu/Zn ratio were elevated. No significant group differences in serum Mg and Mn levels were observed. Serum Ca, Fe, Se, Zn correlated positively with SpO2, being inversely associated with fever, lung damage, and C-reactive protein concentrations. Opposite correlations were observed for Cu and Cu/Zn ratio. In regression models, serum Se levels were inversely associated with lung damage independently of other markers of disease severity, anthropometric, biochemical, and hemostatic parameters. Cu/Zn ratio was also considered as a significant predictor of lower SpO2 in adjusted regression models. Taken together, these findings demonstrated that metal metabolism significantly interferes with COVID-19 pathogenesis, although the causal relations as well as precise mechanisms are yet to be characterized.
Добавил в систему: Тимашев Петр Сергеевич

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Serum Zinc, Copper, and Other Biometals Are Associated with COVID-19 Severity Markersстатья

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