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Translational research into vascular wall function: regulatory effects of systemic and specific factorsстатья
- Автор: Maksimenko Alexander V.
- Журнал: Journal of Translational Science
- Том: 3
- Номер: 2
- Год издания: 2017
- Издательство: Open Access Text
- Местоположение издательства: London, UK
- Первая страница: 1
- Последняя страница: 10
- DOI: 10.15761/jts.1000180
- Аннотация: Development of biomedical techniques has intensified the investigation of endothelial glycocalyx as an individual research object. The effect of vascular wall hydration on progression of pathological lesions, including atherosclerosis, has been revealed and examined. There is evidence that atherosclerosis is associated with water-sulfate and water-sodium exchange. The concept that atherosclerosis is initiated by deficiency of sulfur-containing compounds has been regarded. Glycocalyx protective function against damaging effect of oxidative stress on vascular wall is associated with accumulation and retention of antioxidants on luminal surface of blood vessel. The review deals with protective activity of antioxidant enzyme derivatives, computational methods to determine the principles of the glycocalyx functioning and modeling of the glycocalyx interaction with systemic and specific factors. A limiting influence of crosswind move from clinical practice to life science and contrariwise from life science to clinical practice on the development of translational medicine is emphasized.
- Добавил в систему: Алексашкин Антон Дмитриевич