Аннотация:In the context of emergence of qualitatively new system of economic relations, the transformation of behavioral models and ways of interaction between the main participants of the triple helix model “enterprise/employer – university – state” involved in creation of innovations and development of society is considered in the article. New requirements to these subjects in the new VUCA-world are considered. Special attention is paid to the analysis of existing and prospective forms of cooperation between universities and business structures. The use of project-based learning is proposed, as well as the creation of a technological platform of digital meta-university as one of the sites for the development of innovative projects and training of highly qualified personnel.