Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles

Gongalsky, M.B.; Pervushin, N.V.; Maksutova, D.E.; Tsurikova, U.A.; Putintsev, P.P.; Gyuppenen, O.D.; Evstratova, Y.V.; Shalygina, O.A.; Kopeina, G.S.; Kudryavtsev, A.A.; Zhivotovsky, B.; Osminkina, L.A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 3 ноября 2021 г.

Авторы: Gongalsky Maxim B., Pervushin Nikolay V., Maksutova Daria E., Tsurikova Uliana A., Putintsev Pavel P., Gyuppenen Oleg D., Evstratova Yana V., Shalygina Olga A., Kopeina Gelina S., Kudryavtsev Andrey A., Zhivotovsky Boris, Osminkina Liubov A.
Журнал: Nanomaterials
Том: 11
Номер: 9
Год издания: 2021
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 2167
DOI: 10.3390/nano11092167
Аннотация: Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because of their unique physicochemical properties combined with biodegradability. SiNPs can be obtained in various ways and can have either a non-porous solid (sol-) or porous (por-) structure. In this work, we carry out detailed optical monitoring of sol- and por-SiNP biodegradation using Raman and photoluminescence (PL) micro-spectroscopy. SiNPs were obtained by ultrasound grinding of sol- or por-silicon nanowires, created by silver-assisted chemical etching of crystalline Si with different doping levels. In this case, sol-SiNPs consist of nanocrystals 30 nm in size, while por-SiNPs consist of small 3 nm nanocrystals and 16 nm pores. Both SiNPs show low in vitro cytotoxicity towards MCF-7 and HEK293T cells up to 800 μg/mL. The appearance of the F-band (blue–yellow) PL, as well as a decrease in the intensity of the Raman signal, indicate the gradual dissolution of the sol-SiNPs during 20 days of incubation. At the same time, the rapid dissolution of por-SiNP within 24 h is identified by the quenching of their S-band (red) PL and the disappearance of the Raman signal. The obtained results are important for development of intelligent biodegradable drug delivery systems based on SiNPs.
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