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Energy Metabolism | 2-Oxoglutarate Dehydrogenase Complex,статья Статья в энциклопедии
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 26 января 2022 г.
- Авторы: Bunik Victoria I., Wagner Tristan, Bellinzoni Marco
- Сборник: Encyclopedia of Biological Chemistry III (Third Edition)
- Том: 1
- Год издания: 2021
- Издательство: ELSEVIER ACADEMIC PRESS INC
- Местоположение издательства: 525 B STREET, SUITE 1900, SANDIEGO, USA, CA, 92101-4495
- Первая страница: 259
- Последняя страница: 271
- DOI: 10.1016/B978-0-12-819460-7.00127-4
- Аннотация: 2-Oxoglutarate dehydrogenase (ogdh gene) is an ubiquitous enzyme with additional isoenzymes (ogdhl and dhtkd1 genes) characterized in animals. Using thiamine (vitamin B1) diphosphate, the isoenzymes catalyze oxidative decarboxylation of 2-oxoglutarate or 2-oxoadipate. The coupled generation of succinyl- or glutaryl-CoA and NADH requires self-assembled multienzyme complexes. The complex core is formed by dihydrolipoyl succinyltransferase (dlst gene), binding multiple copies of 2-oxoglutarate dehydrogenase and dihydrolipoamide dehydrogenase (dldh gene). The components stoichiometry depends on the complex sources and/or isolation conditions. Components of the 2-oxoglutarate dehydrogenase complex also catalyze carboligase reaction or reaction with molecular oxygen, which are of potential physiological significance.Keywords: 2-oxoglutarate dehydrogenase; Carboligase; DHTKD1 or E1a; Dihydrolipoamide dehydrogenase; Dihydrolipoamide succinyl transferase; DLDH or DLD or E3; DLST or E2o or ODO2; Multienzyme complex; OGDH or E1o or ODO1 or KGD; OGDHL or E1o; Side reaction with molecular oxygen; Thiamine diphosphate; Vitamin
- Добавил в систему: Буник-Фаренвальд Виктория-Лариса Ивановна